Copper-Catalyzed Oxidation of Alkenes and Heterocycles

Copper-catalyzed intermolecular azidocyanation of aryl alkenes.

A copper-catalyzed Markovnikov-type intermolecular azidocyanation of aryl alkenes has been developed to give a series of α-azido-propanenitriles in moderate to good yields. This method may provide a potential strategy for the synthesis of corresponding 3-amino-2-arylpropanoic acid.

Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.

A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF(3)-containing building blocks from simple starting materials.

Copper-catalyzed bis-arylations of alkenes leading to oxindole derivatives.

A simple and practical copper-catalyzed approach to oxindole derivatives by copper-catalyzed bis-arylation of N-alkyl-N-phenylacrylamides with diaryliodonium triflates has been developed under mild conditions, and the method is of tolerance towards some functional groups in the substrates.

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines.

A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the trea...

Novel Polyaniline Supported Cobalt Catalyzed Aerobic Oxidation of Alkenes